Dylan had his radiation simulation on Monday, neither of us were expecting what happened. Well first off they lay him on the table and line up all the red lasers, kind of like having a scan really. This took about a half hour and he had to lay very still. The areas that will be radiated are the 2 surgery points, the abdomen where the main tumor was removed and the neck where the lymph nodes were removed. The actual radiation will not be for at least a month (after the first round of hot 3F8) but depending on how he responds to that therapy, it may not be until he has completed all 4 rounds (4 months). After the simulation they told us they needed to give him the tattoos! Yes Dylan freaked out and I was worried on how he would handle that. Anyway, we put the numbing cream on, went back up to clinic for a finger stick blood test, then back to radiation for the tattoos. Dylan freaked when he saw the needle, he screamed “I want the machine!” Dylan thought it would be a tattoo gun and wanted that instead of a regular syringe. The first tattoo was done with lots of tears but it really was the fear of the unknown because after the first one he was fine, no more tears and he laid perfectly still, very brave and relaxed, saying “oh that one didn’t hurt, and that one hurt a bit” In total he had 9 tattoos done, but if you ask Dylan he will tell you he had 12 because they had to re-do 3 of them. Well let me tell you, after that Dylan felt on top of the world. He proudly announced to everyone he saw “I have tattoos”. The tattoo's are necessary so that during the radiation therapy the areas are exact, and they need the tattoos to be permanent so they get the same area to line up the lasers every time.
MIBG SCAN
IMPRESSION: Abnormal MIBG with evidence of metastatic disease to bone, grossly unchanged.
CT SCAN – Chest, abdomen, pelvis
FINDINGS: Compare with prior CT chest, abdomen, and pelvis from
Previously described area of soft tissue density in the left thoracic inlet has resolved. There is no evidence of mediastinal or axillary adenopathy. There is no pleural or pericardial effusions. The heart is normal size. The lungs are clear.
The liver, spleen, gallbladder, and kidneys are unremarkable. Multiple clips in the region the left adrenal gland which peritoneum are again noted. The right adrenal cannot be visualized. The bowel is unremarkable. There is no evidence of obstruction. No new masses or adenopathy are identified the abdomen or pelvis. There is no intra-abdominal ascites noted. Stable osseous metastatic disease is identified.
IMPRESSION: Since
1. Soft tissue density left thoracic inlet has resolved
2. 2. No new evidence of lymphadenopathy or intra-abdominal masses
3. Stable diffuse osseous metastatic disease
IN ENGLISH: Since the last scan and lymph node surgery, the neck area has cleared. His liver, kidneys, spleen, gallbladder and bowel are clear with no disease. There are no new solid tumors and the metal clips from the main surgery of tumor removal can be seen.
CT SCAN- Head
FINDINGS: Views of brain fail to demonstrate any evidence for hemorrhage, midline shift, mass effect or abdominal enhancement. The orbits are unremarkable without any evidence for abnormal mass lesion or abnormal enhancement.
The prior CT of the neck dated
A number of mixed sclerotic and lytic areas are identified within the thoracic and lower cervical vertebral bodies. This is suspicious for metastatic disease; however , these findings may also represent treated disease since they are essentially stable when compared to the most recent prior study dated
ENGLISH: There is no evidence of Neuroblastoma in the brain and the lymph nodes. There is Neuroblastoma in the bones of the spine and neck (this has always been there and is stable)
URINE MARKERS
HVA (
VMA (
The previous results in August were
HVA 43
VMA 29
So the urine markers are coming down, which is great. If the HVA or VMA increased with a large jump, it is a sign of disease progression.
SURGICAL PATHOLOGY - BONE MARROWS
DIAGNOSIS:
1) Bone marrow, left posterior iliac crest; biopsy:
Normocellular bone marrow (Approximately 90% cellularity) with trilineage hematopoiessis and numerous fragmented macrophages. The M:E ratio is increased with adequate maturation in all cell lines.
- Megakaryocytes are normal in number and morphology.
- We see no evidence of Neuroblastoma
2) : Bone marrow, right posterior iliac crest; biopsy:
Hypercellular bone marrow (Approximately 30% cellularity) with trilineage hematopoiessis. The M:E ratio is decreased with adequate maturation in all cell lines.
- Megakaryocytes are normal in number and morphology.
- We see no evidence of Neuroblastoma