IMC-A12

Dylan is doing well, he finished the Perifosine/Temsirolimus study after 8 weeks and his work up scans showed a stable result, with no change to his cancer. We decided to cease the study due to the intense leg pain that Dylan experienced and because it did not appear to do anything positive for him. We are now on a new clinical trial, which involves an infusion once a week. This study is a Phase II called IMC-A12 Anti-IGF-I Receptor Monoclonal Antibody. It is a monoclonal antibody that is made in the laboratory and can bind to substances in the body. IMC-A12 blocks the action of a protein needed for cell growth and may kill cancer cells. It is a type of insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Dylan appears to be tolerating this treatment well, his only side effects are a decreased appetite and body itching in the evenings.

Dylan had a visit from his God Father Grant, who came to New York on business from Australia. Dylan was very happy to see him to say the least. They had their usual day at Dave & Busters together, which seems to be their ritual when Grant comes to visit now. I know that Grant eagerly checks Dylan’s website every morning for an update…so hi Grant, sorry for the delay!

Cain is doing great, he played at Radio City and Carnegie Hall in the past 3 weeks. His Bass Guitar playing is continually improving and his dreams of becoming a professional musician are closer each day. The band also had another recording done and Cain will also go to “music camp” again this summer for a few weeks. Not much else is going on in our world, just working and running a household like “normal” people which we are all enjoying very much, it’s amazing how much we take it for granted until your thrown into turmoil. The weather is getting better, so we are venturing out doors more often, which our dog Bear absolutely loves because we try and take him with us everywhere when possible.